Israeli missiles struck a military position near Damascus and Syria's air defence system responded on Saturday, destroying two of them, Syrian state television said.
The extent of the damage is not yet clear although the TV report spoke of material losses at the base.
The reported Iranian compound in Al-Kiswa with new structures completed October
Arab media reports said Israel fired missiles at a military base Iran has been building near the Syrian city of al-Qiswa, reportedly destroying an arms depot.
The missile attack was believed to be the latest in a series of Israeli attacks on Syria, where a six-year civil war has devastated much of the country and displaced millions of citizens.
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Pro-government forces in Syria managed to intercept two of the missiles, Syrian's state-run SANA news agency reported.
The Israeli air force has said it struck arms convoys of the Syrian military and Lebanon's Hezbollah almost 100 times during more than six years of the Syrian war. Whilst he did accept Iran's expanding influence through proxies in Syria and elsewhere, Liberman asserted explicitly that Iranian presence was limited to "some Iranian advisers and experts".
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Only last week Defense Minister Avigdor Liberman shunned Netanyahu's fears and stated that, "there is no physical Iranian military presence at the moment in Syria". In this way, Israeli officials claim that their strikes are counterterror operations as the resistance group is considered a terrorist organization under Israeli law.
A Sky News Arabic report stated some of the missiles were fired from within Lebanon.
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