Barcelona coasted in the first meeting between the two sides this season, winning 5-0 on September 9 thanks to a Messi hat trick and goals from Gerard Pique and Luis Suarez.
The visitors' frustrations were exacerbated by their treatment at the hands of some of the home supporters, with goalkeeper Jasper Cillessen apparently struck by an object thrown from the crowd and Pique having been taunted by chants aimed at him and partner Shakira.
They must now overturn the deficit at the Nou Camp on January 25 to progress to the semi-finals of the Copa del Rey.
Ernesto Valverde was left ruing Barcelona's ineffectiveness in front of goal after its 29-match unbeaten run was ended by Espanyol in the first leg of the Copa del Rey quarterfinals. "We are lucky to have that game at home, and we will have to win whatever happens".
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"It doesn't hurt to lose our streak here".
Lionel Messi saw a penalty saved just after the hour mark and created a decent amount of chances in a game they dominated. "It can be turned around next week". It was hard for us, but we had it under control. Espanyol valiantly resisted Barcelona's assaults and found the opening within the last five minutes of the game. "But the team had never been threatened all game apart from a few dead ball situations", he said.
He added: "One day the defeat had to come".
"But their approach was to sit back and wait for us, closing any interior spaces".
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Those that came in - Denis, Lucas Digne, Carles Alena and Aleix Vidal - struggled to have an impact, but Valverde defended his team selection.
"The result is not good for us".
"We played with the same players in Vigo [against Celta] and I am happy with them", the coach said.
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