Former White House Chief of Staff Reince Priebus, who attended the dinner, called Wolf's routine: "An R/X rated spectacle that started poorly and ended up in the bottom of the canyon". "Oh, I know. Aunt Coulter", Wolf said.
Wolf is pushing back and claims that her attacks on Sanders were not related to her appearance.
The performance, which was televised live on C-SPAN, was fiercely debated on social media Sunday, with several high-profile journalists taking issue with Wolf's harsh jokes.
Kumail Nanjani, actor and co-writer of the film The Big Sick, said Sanders did not deserve any pity.
Jaire Alexander taken by Green Bay
One of the coolest moments of the night came shortly after the Baltimore Ravens selected Lamar Jackson late in the first round. He's one, when you watch him play, you can feel him close space when the ball's in the air, both playing forward and backward.
Wolf also took on Fox News and CNN, Trump's favorite media punching bag.
Wolf went on to mock everything from her truthfulness to her appearance and Southern roots, in a roast that had some in the audience laughing and left others in stony silence.
Her next remarks were saved for First Daughter and top White House aide Ivanka Trump, who she said was "supposed to be an advocate for women" but ended up being as helpful to women "as an empty box of tampons".
Trump got his own shots in on the dinner from afar, telling the crowd in MI he was in a no-win situation. Is it Sarah Sanders, Sarah Huckabee Sanders.
Dallas Cowboy Great Hanging Up The Cleats for the Booth
The 49ers have traded right tackle Trent Brown to the Patriots, a day after drafting Mike McGlinchey as his replacement. Jason Witten is thinking of relinquishing his spot on America's Team for one at the Worldwide Leader in Sports.
But conservative consternation and Trump's protest of the event may finally help build bipartisan consensus for the brewing calls to put an end to the White House correspondents dinner, which critics have noted has evolved into a glitzy schmoozefest that allows journalists to get too close to their sources while simultaneously sewing discontent between politicians and the press. "I look forward to locking you all up in the coming years!" Who blames Trump for not going?
After one crass joke drew groans in the Washington Hilton ballroom, Wolf, an alumnus of The Daily Show who has a Netflix talk show coming next month, laughed and said: "Yeah, shoulda done more research before you got me to do this". "I hope she never works again!"
"Is this better than that phony Washington White House Correspondents' Dinner?"
It was the second dinner held in a row where Mr Trump had failed to attend.
Mentioning how CNN likes to "break news", she said, "You did it".
Trump, Macron 'bromance' draws late night laughs in US
German Chancellor Angela Merkel will make a similar effort when she visits later this week. Emmanuel Macron came, saw and conquered Washington this week.