The hurricane, which is likely to be a Category 3, with winds of almost 130 miles per hour when it makes landfall, is expected to hit the Carolinas late Thursday night before making its way inland.
In fact, the entire storm is growing as it approaches the Carolina coastline, where it is expected to hit on Thursday night.
"The combination of storm surge and the tide will cause normally dry areas near the coast to be flooded by rising waters moving inland from the shoreline".
He added islands to the south such as Barbados and St Lucia are expected to experience some wind from the storm.
At the same time Florence is expected to make its landfall, another storm, Isaac, is forecast to be at or near hurricane strength as it moves across the Lesser Antilles and into the eastern Caribbean Sea.
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The center says the storm is moving west-northwest at 17 miles per hour, and has maximum sustained winds of about 130 miles per hour. He said it is expected to produce two to three feet of rain, mostly centred on North Carolina, Virginia, and the northern sections of SC.
Hurricane Florence's size is "staggering", National Hurricane Center Director Ken Graham warned. "The full brunt of a major hurricane (Category 4 or so), then perhaps 30 to 40 inches of rainfall if the storm stalls".
Officials have called for the mandatory evacuation of more than 1.4 million coastal residents across the Carolinas and Virginia. Other counties are evacuating low lying and flood prone areas.
North Carolina has only been hit by one Category 4 storm since reliable record keeping began in the 1850s. Its centre will move between Bermuda and the Bahamas on Tuesday and Wednesday and approach the coast of SC or North Carolina on Thursday, the National Hurricane Center said. "That, folks, is extremely life-threatening".
U.S. President Donald Trump speaks during an Oval Office meeting on hurricane preparations for Hurricane Florence at the White House in Washington, U.S., September 11, 2018.
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The storm's potential path also includes half a dozen nuclear power plants, pits holding coal-ash and other industrial waste, and numerous hog farms that store animal waste in massive open-air lagoons.
"If it decides to come here, we're gone", he said.
President Trump approved an emergency declaration for North Carolina on Monday, and tweeted that his administration will be there for to help those in need.
A special NY task force is heading south to help with Hurricane Florence. Even if you've ridden out storms before, this one is different.
He said Florence could rival the impact of Hurricane Hugo, which wreaked $7bn (£5.3bn) in damage and claimed 49 lives in 1989.
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